GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'.

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro

In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions. We analyzed the changes of overall network activity and network-wide burst frequency between baseli...

NMDA and AMPA Receptors Over the Lifespan Reciprocal Changes in Hippocampal Granule Cell Synaptic Commitment: Developmentally Regulated

Prolonged reciprocal signaling via NMDA and GABA receptors at a retinal ribbon synapse.

AMPA and GABAA receptors mediate most of the fast signaling in the CNS. However, the retina must, in addition, also convey slow and sustained signals. Given that AMPA and GABAA receptors desensitize quickly in the continuous presence of agonist, how are sustained excitatory and inhibitory signals transmitted reliably across retinal synapses? Reciprocal synapses between bipolar and amacrine cell...

Dopamine- induced hypophagia is mediated via NMDA and mGlu1 receptors in chicken

Background: Feeding behavior is regulated by a complex network which interacts via diverse signals from central and peripheral tissues. It is known dopaminergic and glutamatergic systems have crucial role on food intake regulation but scarce reports exist on their interaction in appetite regulation in broilers. OBJECTIVES: The present study was designed to examine the role of glutamatergic syst...

Synaptic commitment: developmentally regulated reciprocal changes in hippocampal granule cell NMDA and AMPA receptors over the lifespan.

Synaptic transmission in hippocampal field CA1 is largely N-methyl-d-aspartate receptor (NMDA(R)) dependent during the early postnatal period. It becomes increasingly mediated by alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) receptors until an adult ratio of AMPA to NMDA receptors is achieved. It is shown here that increases in the AMPA receptor (AMPA(R))-mediated field potential...